Immediate antiviral therapy appears to restrict resting CD4(+) cell HIV-1 infection without accelerating the decay of latent infection

HIV type 1 (HIV-1) persists within resting CD4(+) T cells despite antiretroviral therapy (ART). To better understand the kinetics by which resting cell infection (RCI) is established, we developed a mathematical model that accurately predicts (r = 0.65, P = 2.5 × 10(−4)) the initial frequency of RCI...

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Detalhes bibliográficos
Main Authors: Archin, Nancie M., Vaidya, Naveen K., Kuruc, JoAnn D., Liberty, Abigail L., Wiegand, Ann, Kearney, Mary F., Cohen, Myron S., Coffin, John M., Bosch, Ronald J., Gay, Cynthia L., Eron, Joseph J., Margolis, David M., Perelson, Alan S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386138/
https://ncbi.nlm.nih.gov/pubmed/22645358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1120248109
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