Functional genomics identifies therapeutic targets for MYC-driven cancer

MYC oncogene family members are broadly implicated in human cancers, yet are considered “undruggable” as they encode transcription factors. MYC also carries out essential functions in proliferative tissues, suggesting that its inhibition could cause severe side effects. We elected to identify synthe...

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Detalhes bibliográficos
Main Authors: Toyoshima, Masafumi, Howie, Heather L., Imakura, Maki, Walsh, Ryan M., Annis, James E., Chang, Aaron N., Frazier, Jason, Chau, B. Nelson, Loboda, Andrey, Linsley, Peter S., Cleary, Michele A., Park, Julie R., Grandori, Carla
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386069/
https://ncbi.nlm.nih.gov/pubmed/22623531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1121119109
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