Novel cooperative pathway of c-Myc and Furin, a pro-protein convertase, in cell proliferation as a therapeutic target in ovarian cancers

c-Myc is a master regulator of various oncogenic functions in many types of human cancers. However, direct c-Myc-targeted therapy has not been successful in the clinic. Here, we explored a novel therapeutic target, which shows synthetic lethality in c-Myc-driven ovarian cancers, and examined the mol...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Hasegawa-Minato, Junko, Toyoshima, Masafumi, Ishibashi, Masumi, Zhang, Xuewei, Shigeta, Shogo, Grandori, Carla, Kitatani, Kazuyuki, Yaegashi, Nobuo
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5790477/
https://ncbi.nlm.nih.gov/pubmed/29423060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23322
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