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Synthetic Lethal Screens as a Means to Understand and Treat MYC-Driven Cancers

Although therapeutics against MYC could potentially be used against a wide range of human cancers, MYC-targeted therapies have proven difficult to develop. The convergence of breakthroughs in human genomics and in gene silencing using RNA interference (RNAi) have recently allowed functional interrog...

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Autors principals: Cermelli, Silvia, Jang, In Sock, Bernard, Brady, Grandori, Carla
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3935389/
https://ncbi.nlm.nih.gov/pubmed/24591535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a014209
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