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Nascent RNA structure modulates the transcriptional dynamics of RNA polymerases

RNA polymerase pausing represents an important mechanism of transcriptional regulation. In this study, we use a single-molecule transcription assay to investigate the effect of template base-pair composition on pausing by RNA polymerase II and the evolutionarily distinct mitochondrial polymerase Rpo...

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Autori principali: Zamft, Bradley, Bintu, Lacramioara, Ishibashi, Toyotaka, Bustamante, Carlos
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384149/
https://ncbi.nlm.nih.gov/pubmed/22615360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1205063109
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