Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein

Here, we use single-molecule techniques to study the aggregation of α-synuclein, the protein whose misfolding and deposition is associated with Parkinson's disease. We identify a conformational change from the initially formed oligomers to stable, more compact proteinase-K-resistant oligomers a...

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Bibliografiske detaljer
Main Authors: Cremades, Nunilo, Cohen, Samuel I.A., Deas, Emma, Abramov, Andrey Y., Chen, Allen Y., Orte, Angel, Sandal, Massimo, Clarke, Richard W., Dunne, Paul, Aprile, Francesco A., Bertoncini, Carlos W., Wood, Nicholas W., Knowles, Tuomas P.J., Dobson, Christopher M., Klenerman, David
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383996/
https://ncbi.nlm.nih.gov/pubmed/22632969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.03.037
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