Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein

Here, we use single-molecule techniques to study the aggregation of α-synuclein, the protein whose misfolding and deposition is associated with Parkinson's disease. We identify a conformational change from the initially formed oligomers to stable, more compact proteinase-K-resistant oligomers a...

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Hauptverfasser: Cremades, Nunilo, Cohen, Samuel I.A., Deas, Emma, Abramov, Andrey Y., Chen, Allen Y., Orte, Angel, Sandal, Massimo, Clarke, Richard W., Dunne, Paul, Aprile, Francesco A., Bertoncini, Carlos W., Wood, Nicholas W., Knowles, Tuomas P.J., Dobson, Christopher M., Klenerman, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383996/
https://ncbi.nlm.nih.gov/pubmed/22632969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.03.037
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