Enzymatic Removal of Ribonucleotides from DNA Is Essential for Mammalian Genome Integrity and Development

The presence of ribonucleotides in genomic DNA is undesirable given their increased susceptibility to hydrolysis. Ribonuclease (RNase) H enzymes that recognize and process such embedded ribonucleotides are present in all domains of life. However, in unicellular organisms such as budding yeast, they...

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Autors principals: Reijns, Martin A.M., Rabe, Björn, Rigby, Rachel E., Mill, Pleasantine, Astell, Katy R., Lettice, Laura A., Boyle, Shelagh, Leitch, Andrea, Keighren, Margaret, Kilanowski, Fiona, Devenney, Paul S., Sexton, David, Grimes, Graeme, Holt, Ian J., Hill, Robert E., Taylor, Martin S., Lawson, Kirstie A., Dorin, Julia R., Jackson, Andrew P.
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383994/
https://ncbi.nlm.nih.gov/pubmed/22579044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.04.011
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