Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma

Multiple myeloma (MM) cells are characterized by high protein synthesis resulting in chronic endoplasmic reticulum (ER) stress, which is adaptively managed by the unfolded protein response. Inositol-requiring enzyme 1α (IRE1α) is activated to splice X-box binding protein 1 (XBP1) mRNA, thereby incre...

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Main Authors: Mimura, Naoya, Fulciniti, Mariateresa, Gorgun, Gullu, Tai, Yu-Tzu, Cirstea, Diana, Santo, Loredana, Hu, Yiguo, Fabre, Claire, Minami, Jiro, Ohguchi, Hiroto, Kiziltepe, Tanyel, Ikeda, Hiroshi, Kawano, Yutaka, French, Maureen, Blumenthal, Martina, Tam, Victor, Kertesz, Nathalie L., Malyankar, Uriel M., Hokenson, Mark, Pham, Tuan, Zeng, Qingping, Patterson, John B., Richardson, Paul G., Munshi, Nikhil C., Anderson, Kenneth C.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society of Hematology 2012
נושאים:
Lymphoid Neoplasia
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382937/
https://ncbi.nlm.nih.gov/pubmed/22538852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-07-366633
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