Dual inhibition of canonical and non-canonical NF-κB pathways demonstrates significant anti-tumor activities in multiple myeloma

PURPOSE: NF-κB transcription factor plays a key role in the pathogenesis of multiple myeloma (MM) in the context of the bone marrow (BM) microenvironment. Both canonical and non-canonical pathways contribute to total NF-κB activity. Recent studies have demonstrated a critical role for the non-canoni...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Fabre, Claire, Mimura, Naoya, Bobb, Kathryn, Kong, Sun-Young, Gorgun, Güllü, Cirstea, Diana, Hu, Yiguo, Minami, Jiro, Ohguchi, Hiroto, Zhang, Jie, Meshulam, Jeffrey, Carrasco, Ruben D., Tai, Yu-Tzu, Richardson, Paul G., Hideshima, Teru, Anderson, Kenneth C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4456190/
https://ncbi.nlm.nih.gov/pubmed/22806876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-0779
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