Selective and potent Akt inhibition triggers anti-myeloma activities and enhances fatal endoplasmic reticulum stress induced by proteasome inhibition

The PI3K/Akt pathway plays a crucial role in the pathogenesis of multiple myeloma (MM) in the bone marrow (BM) milieu. However, efficacy of selective and potent Akt inhibition has not yet been fully elucidated. In this study, we therefore examined the biologic impact of selective and potent Akt inhi...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Mimura, Naoya, Hideshima, Teru, Shimomura, Toshiyasu, Suzuki, Rikio, Ohguchi, Hiroto, Rizq, Ola, Kikuchi, Shohei, Yoshida, Yasuhiro, Cottini, Francesca, Jakubikova, Jana, Cirstea, Diana, Gorgun, Gullu, Minami, Jiro, Tai, Yu-Tzu, Richardson, Paul G., Utsugi, Teruhiro, Iwama, Atsushi, Anderson, Kenneth C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140659/
https://ncbi.nlm.nih.gov/pubmed/24934808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-3652
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg