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K-RAS GTPase- and B-RAF kinase–mediated T-cell tolerance defects in rheumatoid arthritis
Autoantibodies to common autoantigens and neoantigens, such as IgG Fc and citrullinated peptides, are immunological hallmarks of rheumatoid arthritis (RA). We examined whether a failure in maintaining tolerance is mediated by defects in T-cell receptor activation threshold settings. RA T cells respo...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3382540/ https://ncbi.nlm.nih.gov/pubmed/22615393 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1117640109 |
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