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ERK-dependent T-cell receptor threshold calibration in rheumatoid arthritis
Immune responses to citrullinated neoantigens and clinical efficacy of costimulation blockade indicate a general defect in maintaining T-cell tolerance in rheumatoid arthritis (RA). To examine whether TCR threshold calibration contributes to disease pathogenesis, signaling in RA T cells was quantifi...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2828269/ https://ncbi.nlm.nih.gov/pubmed/20007589 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0901784 |
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