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Telomerase insufficiency in rheumatoid arthritis

In rheumatoid arthritis (RA), chronically stimulated T lymphocytes sustain tissue-destructive joint inflammation. Both naïve and memory T cells in RA are prematurely aged with accelerated loss of telomeres suggesting excessive proliferative pressure or inadequate telomeric maintenance. Upon stimulat...

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Detalhes bibliográficos
Main Authors: Fujii, Hiroshi, Shao, Lan, Colmegna, Inés, Goronzy, Jörg J., Weyand, Cornelia M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2657451/
https://ncbi.nlm.nih.gov/pubmed/19255426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811332106
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