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IL-7– and IL-15–mediated TCR sensitization enables T cell responses to self-antigens
Regulation of the ERK pathway is intimately involved in determining whether TCR stimulation is productive or induces anergy. T cells from patients with rheumatoid arthritis (RA) have increased ERK responsiveness which may be relevant for disease pathogenesis. Inflammatory cytokines such as TNF-α did...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3574821/ https://ncbi.nlm.nih.gov/pubmed/23325887 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201620 |
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