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IL-7– and IL-15–mediated TCR sensitization enables T cell responses to self-antigens
Regulation of the ERK pathway is intimately involved in determining whether TCR stimulation is productive or induces anergy. T cells from patients with rheumatoid arthritis (RA) have increased ERK responsiveness which may be relevant for disease pathogenesis. Inflammatory cytokines such as TNF-α did...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3574821/ https://ncbi.nlm.nih.gov/pubmed/23325887 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201620 |
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