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Signal inhibition by the dual-specific phosphatase 4 impairs T cell-dependent B-cell responses with age
T cell-dependent B-cell responses decline with age, suggesting defective CD4 T-cell function. CD4 memory T cells from individuals older than 65 y displayed increased and sustained transcription of the dual-specific phosphatase 4 (DUSP4) that shortened expression of CD40-ligand (CD40L) and inducible...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3326453/ https://ncbi.nlm.nih.gov/pubmed/22434910 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1109797109 |
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