Constitutive activation of p38 MAPK in tumor cells contributes to osteolytic bone lesions in multiple myeloma

Bone destruction is a hallmark of multiple myeloma and affects more than 80% of patients. However, current therapy is unable to completely cure and/or prevent bone lesions. Although it is accepted that myeloma cells mediate bone destruction by inhibition of osteoblasts and activation of osteoclasts,...

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Autori principali: Yang, Jing, He, Jin, Wang, Ji, Cao, Yabing, Ling, Jianhua, Qian, Jianfei, Lu, Yong, Li, Haiyan, Zheng, Yuhuan, Lan, Yongsheng, Hong, Sungyoul, Matthews, Jairo, Starbuck, Michael W, Navone, Nora M, Orlowski, Robert Z., Lin, Pei, Kwak, Larry W., Yi, Qing
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381862/
https://ncbi.nlm.nih.gov/pubmed/22425892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2012.71
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