Novel phosphatidylinositol 3-kinase inhibitor NVP-BKM120 induces apoptosis in myeloma cells and shows synergistic anti-myeloma activity with dexamethasone

NVP-BKM120 is a novel phosphatidylinositol 3-kinase (PI3K) inhibitor and is currently being investigated in phase I clinical trials in solid tumors. This study aimed to evaluate the therapeutic efficacy of BKM120 in multiple myeloma (MM). BKM120 induces cell growth inhibition and apoptosis in both M...

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Detalhes bibliográficos
Main Authors: Zheng, Yuhuan, Yang, Jing, Qian, Jianfei, Zhang, Liang, Lu, Yong, Li, Haiyan, Lin, Heather, Lan, Yongsheng, Liu, Zhiqiang, He, Jin, Hong, Sungyoul, Thomas, Sheeba, Shah, Jatin, Baladandayuthapani, Veera, Kwak, Larry W., Yi, Qing
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4212830/
https://ncbi.nlm.nih.gov/pubmed/22207485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-011-0849-9
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