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NVP-BKM120 inhibits colon cancer growth via FoxO3a-dependent PUMA induction
NVP-BKM120, a potent and highly selective PI3K inhibitor, is currently being investigated in phase I/II clinical trials. The mechanisms of action of NVP-BKM120 in colon cancer cells are unclear. In the present study, we investigated how NVP-BKM120 suppresses colon cancer cells growth and potentiates...
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| Publicado no: | Oncotarget |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals LLC
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5669949/ https://ncbi.nlm.nih.gov/pubmed/29137323 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20943 |
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