The β-Globin Locus Control Region in Combination With the EF1α Short Promoter Allows Enhanced Lentiviral Vector-mediated Erythroid Gene Expression With Conserved Multilineage Activity

Some gene therapy strategies are compromised by the levels of gene expression required for therapeutic benefit, and also by the breadth of cell types that require correction. We designed a lentiviral vector system in which a transgene is under the transcriptional control of the short form of constit...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Montiel-Equihua, Claudia A, Zhang, Lin, Knight, Sean, Saadeh, Heba, Scholz, Simone, Carmo, Marlene, Alonso-Ferrero, Maria E, Blundell, Michael P, Monkeviciute, Aiste, Schulz, Reiner, Collins, Mary, Takeuchi, Yasuhiro, Schmidt, Manfred, Fairbanks, Lynette, Antoniou, Michael, Thrasher, Adrian J, Gaspar, H Bobby
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2012
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381857/
https://ncbi.nlm.nih.gov/pubmed/22434141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.50
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