The β-Globin Locus Control Region in Combination With the EF1α Short Promoter Allows Enhanced Lentiviral Vector-mediated Erythroid Gene Expression With Conserved Multilineage Activity

Some gene therapy strategies are compromised by the levels of gene expression required for therapeutic benefit, and also by the breadth of cell types that require correction. We designed a lentiviral vector system in which a transgene is under the transcriptional control of the short form of constit...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Montiel-Equihua, Claudia A, Zhang, Lin, Knight, Sean, Saadeh, Heba, Scholz, Simone, Carmo, Marlene, Alonso-Ferrero, Maria E, Blundell, Michael P, Monkeviciute, Aiste, Schulz, Reiner, Collins, Mary, Takeuchi, Yasuhiro, Schmidt, Manfred, Fairbanks, Lynette, Antoniou, Michael, Thrasher, Adrian J, Gaspar, H Bobby
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2012
Gaiak:
Original Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381857/
https://ncbi.nlm.nih.gov/pubmed/22434141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.50
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