Doxycycline Stabilizes Vulnerable Plaque via Inhibiting Matrix Metalloproteinases and Attenuating Inflammation in Rabbits

Enhanced matrix metalloproteinases (MMPs) activity is implicated in the process of atherosclerotic plaque instability. We hypothesized that doxycycline, a broad MMPs inhibitor, was as effective as simvastatin in reducing the incidence of plaque disruption. Thirty rabbits underwent aortic balloon inj...

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Autori principali: Dong, Mei, Zhong, Lin, Chen, Wen Qiang, Ji, Xiao Ping, Zhang, Mei, Zhao, Yu Xia, Li, Li, Yao, Gui Hua, Zhang, Peng Fei, Zhang, Cheng, Zhang, Lei, Zhang, Yun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3380900/
https://ncbi.nlm.nih.gov/pubmed/22737253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039695
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