Doxycycline Stabilizes Vulnerable Plaque via Inhibiting Matrix Metalloproteinases and Attenuating Inflammation in Rabbits

Enhanced matrix metalloproteinases (MMPs) activity is implicated in the process of atherosclerotic plaque instability. We hypothesized that doxycycline, a broad MMPs inhibitor, was as effective as simvastatin in reducing the incidence of plaque disruption. Thirty rabbits underwent aortic balloon inj...

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Autors principals: Dong, Mei, Zhong, Lin, Chen, Wen Qiang, Ji, Xiao Ping, Zhang, Mei, Zhao, Yu Xia, Li, Li, Yao, Gui Hua, Zhang, Peng Fei, Zhang, Cheng, Zhang, Lei, Zhang, Yun
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3380900/
https://ncbi.nlm.nih.gov/pubmed/22737253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039695
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