Doxycycline Stabilizes Vulnerable Plaque via Inhibiting Matrix Metalloproteinases and Attenuating Inflammation in Rabbits

Enhanced matrix metalloproteinases (MMPs) activity is implicated in the process of atherosclerotic plaque instability. We hypothesized that doxycycline, a broad MMPs inhibitor, was as effective as simvastatin in reducing the incidence of plaque disruption. Thirty rabbits underwent aortic balloon inj...

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Detalhes bibliográficos
Main Authors: Dong, Mei, Zhong, Lin, Chen, Wen Qiang, Ji, Xiao Ping, Zhang, Mei, Zhao, Yu Xia, Li, Li, Yao, Gui Hua, Zhang, Peng Fei, Zhang, Cheng, Zhang, Lei, Zhang, Yun
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3380900/
https://ncbi.nlm.nih.gov/pubmed/22737253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039695
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