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Continual low-level MEK inhibition ameliorates cardio-facio-cutaneous phenotypes in zebrafish
Cardio-facio-cutaneous (CFC) syndrome is caused by germline mutations in KRAS, BRAF and MEK1/2. The highly selective and potent MEK inhibitors that have been developed as anti-cancer agents hold potential as therapeutics for CFC syndrome. We have previously shown that the effects of CFC mutations on...
Gorde:
| Egile Nagusiak: | , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
The Company of Biologists Limited
2012
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3380717/ https://ncbi.nlm.nih.gov/pubmed/22301711 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.008672 |
| Etiketak: |
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