Continual low-level MEK inhibition ameliorates cardio-facio-cutaneous phenotypes in zebrafish

Cardio-facio-cutaneous (CFC) syndrome is caused by germline mutations in KRAS, BRAF and MEK1/2. The highly selective and potent MEK inhibitors that have been developed as anti-cancer agents hold potential as therapeutics for CFC syndrome. We have previously shown that the effects of CFC mutations on...

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Bibliographic Details
Main Authors: Anastasaki, Corina, Rauen, Katherine A., Patton, E. Elizabeth
Format: Artigo
Language:Inglês
Published: The Company of Biologists Limited 2012
Subjects:
Research Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3380717/
https://ncbi.nlm.nih.gov/pubmed/22301711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.008672
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