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The P(2)′ residue is a key determinant of mesotrypsin specificity: Engineering a high affinity inhibitor with anticancer activity

PRSS3/mesotrypsin is an atypical isoform of trypsin, the upregulation of which has been implicated in promoting tumor progression. Mesotrypsin inhibitors could potentially provide valuable research tools and novel therapeutics, but small molecule trypsin inhibitors have low affinity and little selec...

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書誌詳細
主要な著者: Salameh, Moh’d A., Soares, Alexei S., Hockla, Alexandra, Radisky, Derek C., Radisky, Evette S.
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3380622/
https://ncbi.nlm.nih.gov/pubmed/21806544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20110788
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