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The P(2)′ residue is a key determinant of mesotrypsin specificity: Engineering a high affinity inhibitor with anticancer activity
PRSS3/mesotrypsin is an atypical isoform of trypsin, the upregulation of which has been implicated in promoting tumor progression. Mesotrypsin inhibitors could potentially provide valuable research tools and novel therapeutics, but small molecule trypsin inhibitors have low affinity and little selec...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3380622/ https://ncbi.nlm.nih.gov/pubmed/21806544 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20110788 |
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