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Presence versus absence of hydrogen bond donor Tyr-39 influences interactions of cationic trypsin and mesotrypsin with protein protease inhibitors

Mesotrypsin displays unusual resistance to inhibition by polypeptide trypsin inhibitors and cleaves some such inhibitors as substrates, despite a high degree of conservation with other mammalian trypsins. Substitution of Arg for the generally conserved Gly-193 has been implicated as a critical deter...

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מידע ביבליוגרפי
Main Authors: Salameh, Moh'd A, Soares, Alexei S, Alloy, Alexandre, Radisky, Evette S
פורמט: Artigo
שפה:Inglês
יצא לאור: Wiley Subscription Services, Inc., A Wiley Company 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537232/
https://ncbi.nlm.nih.gov/pubmed/22610453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2097
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