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Intrinsic Nucleic Acid Dynamics Modulates HIV-1 Nucleocapsid Protein Binding to Its Targets

HIV-1 nucleocapsid protein (NC) is involved in the rearrangement of nucleic acids occurring in key steps of reverse transcription. The protein, through its two zinc fingers, interacts preferentially with unpaired guanines in single-stranded sequences. In mini-cTAR stem-loop, which corresponds to the...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Bazzi, Ali, Zargarian, Loussiné, Chaminade, Françoise, De Rocquigny, Hugues, René, Brigitte, Mély, Yves, Fossé, Philippe, Mauffret, Olivier
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3380039/
https://ncbi.nlm.nih.gov/pubmed/22745685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038905
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