DNA Polymerase Eta Participates in the Mutagenic Bypass of Adducts Induced by Benzo[a]pyrene Diol Epoxide in Mammalian Cells

Y-family DNA-polymerases have larger active sites that can accommodate bulky DNA adducts allowing them to bypass these lesions during replication. One member, polymerase eta (pol eta), is specialized for the bypass of UV-induced thymidine-thymidine dimers, correctly inserting two adenines. Loss of p...

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Detaylı Bibliyografya
Asıl Yazarlar: Klarer, Alden C., Stallons, L. Jay, Burke, Tom J., Skaggs, Robert L., McGregor, W. Glenn
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2012
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3380003/
https://ncbi.nlm.nih.gov/pubmed/22745795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039596
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