In Vivo Role of Focal Adhesion Kinase in Regulating Pancreatic β-Cell Mass and Function Through Insulin Signaling, Actin Dynamics, and Granule Trafficking

Focal adhesion kinase (FAK) acts as an adaptor at the focal contacts serving as a junction between the extracellular matrix and actin cytoskeleton. Actin dynamics is known as a determinant step in insulin secretion. Additionally, FAK has been shown to regulate insulin signaling. To investigate the e...

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Bibliografiske detaljer
Main Authors: Cai, Erica P., Casimir, Marina, Schroer, Stephanie A., Luk, Cynthia T., Shi, Sally Yu, Choi, Diana, Dai, Xiao Qing, Hajmrle, Catherine, Spigelman, Aliya F., Zhu, Dan, Gaisano, Herbert Y., MacDonald, Patrick E., Woo, Minna
Format: Artigo
Sprog:Inglês
Udgivet: American Diabetes Association 2012
Fag:
Islet Studies
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3379666/
https://ncbi.nlm.nih.gov/pubmed/22498697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1344
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