Vinculin–actin interaction couples actin retrograde flow to focal adhesions, but is dispensable for focal adhesion growth

In migrating cells, integrin-based focal adhesions (FAs) assemble in protruding lamellipodia in association with rapid filamentous actin (F-actin) assembly and retrograde flow. How dynamic F-actin is coupled to FA is not known. We analyzed the role of vinculin in integrating F-actin and FA dynamics...

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Detalhes bibliográficos
Main Authors: Thievessen, Ingo, Thompson, Peter M., Berlemont, Sylvain, Plevock, Karen M., Plotnikov, Sergey V., Zemljic-Harpf, Alice, Ross, Robert S., Davidson, Michael W., Danuser, Gaudenz, Campbell, Sharon L., Waterman, Clare M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3704983/
https://ncbi.nlm.nih.gov/pubmed/23836933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201303129
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