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Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation
We report here the 1.62 Å crystal structure of an intramolecular quadruplex DNA formed from a sequence in the promoter region of the c-kit gene. This is the first reported crystal structure of a promoter quadruplex and the first observation of localized magnesium ions in a quadruplex structure. The...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2012
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3378867/ https://ncbi.nlm.nih.gov/pubmed/22287624 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks023 |
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