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Predictive modelling of topology and loop variations in dimeric DNA quadruplex structures

We have used a combination of simulated annealing (SA), molecular dynamics (MD) and locally enhanced sampling (LES) methods in order to predict the favourable topologies and loop conformations of dimeric DNA quadruplexes with T2 or T3 loops. This follows on from our previous MD simulation studies on...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Hazel, Pascale, Parkinson, Gary N, Neidle, Stephen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2006
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1449907/
https://ncbi.nlm.nih.gov/pubmed/16641317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl182
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