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Predictive modelling of topology and loop variations in dimeric DNA quadruplex structures

We have used a combination of simulated annealing (SA), molecular dynamics (MD) and locally enhanced sampling (LES) methods in order to predict the favourable topologies and loop conformations of dimeric DNA quadruplexes with T2 or T3 loops. This follows on from our previous MD simulation studies on...

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Main Authors: Hazel, Pascale, Parkinson, Gary N, Neidle, Stephen
格式: Artigo
語言:Inglês
出版: Oxford University Press 2006
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1449907/
https://ncbi.nlm.nih.gov/pubmed/16641317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl182
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