Soluble CD23 Controls IgE Synthesis and Homeostasis in Human B Cells

CD23, the low affinity receptor for IgE, exists in membrane and soluble forms. Soluble CD23 fragments are released from membrane CD23 by the endogenous metalloprotease, ADAM10. When purified tonsil B cells are incubated with IL-4 and anti-CD40 to induce class switching to IgE in vitro, membrane CD23...

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Bibliografiske detaljer
Main Authors: Cooper, Alison M., Hobson, Philip S., Jutton, Mark R., Kao, Michael W., Drung, Binia, Schmidt, Boris, Fear, David J., Beavil, Andrew J., McDonnell, James M., Sutton, Brian J., Gould, Hannah J.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378639/
https://ncbi.nlm.nih.gov/pubmed/22393152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1102689
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