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Combination of MEK and SRC inhibition suppresses melanoma cell growth and invasion
The RAS-RAF-MEK-ERK pathway is deregulated in over 90% of malignant melanomas and targeting MEK as central kinase of this pathway is currently tested in clinical trials. However, dose-limiting side effects are observed, and MEK inhibitors that sufficiently reduce ERK activation in patients show a lo...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3378628/ https://ncbi.nlm.nih.gov/pubmed/22310287 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.25 |
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