Histone deacetylase inhibition increases levels of choline kinase alpha and phosphocholine facilitating non-invasive imaging in human cancers

Histone deacetylase (HDAC) inhibitors are currently approved for cutaneous T-cell lymphoma and are in mid-late stage trials for other cancers. The HDAC inhibitors LAQ824 and SAHA increase phosphocholine (PC) levels in human colon cancer cells and tumor xenografts as observed by magnetic resonance sp...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Beloueche-Babari, Mounia, Arunan, Vaitha, Troy, Helen, te Poele, Robert H, Fong, Anne-Christine Wong Te, Jackson, L Elizabeth, Payne, Geoffrey S, Griffiths, John R, Judson, Ian R, Workman, Paul, Leach, Martin O, Chung, Yuen-Li
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2011
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378496/
https://ncbi.nlm.nih.gov/pubmed/22194463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-2688
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