Histone deacetylase inhibition increases levels of choline kinase alpha and phosphocholine facilitating non-invasive imaging in human cancers

Histone deacetylase (HDAC) inhibitors are currently approved for cutaneous T-cell lymphoma and are in mid-late stage trials for other cancers. The HDAC inhibitors LAQ824 and SAHA increase phosphocholine (PC) levels in human colon cancer cells and tumor xenografts as observed by magnetic resonance sp...

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Main Authors: Beloueche-Babari, Mounia, Arunan, Vaitha, Troy, Helen, te Poele, Robert H, Fong, Anne-Christine Wong Te, Jackson, L Elizabeth, Payne, Geoffrey S, Griffiths, John R, Judson, Ian R, Workman, Paul, Leach, Martin O, Chung, Yuen-Li
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378496/
https://ncbi.nlm.nih.gov/pubmed/22194463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-2688
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