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Autophagosome assembly and cargo capture in the distal axon

Autophagy is an essential lysosomal degradation pathway in neurons, yet the basic mechanisms involved are poorly understood. Here, we discuss our recent study in which we define autophagosome dynamics in primary neurons. We find that autophagosomes initiate at the distal tip of the axon in primary n...

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Main Authors: Maday, Sandra, Holzbaur, Erika L.F.
Formato: Artigo
Idioma:Inglês
Publicado: Landes Bioscience 2012
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378425/
https://ncbi.nlm.nih.gov/pubmed/22617438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.20055
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