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Dynactin Is Required for Transport Initiation from the Distal Axon
Dynactin is a required cofactor for the minus-end directed microtubule motor cytoplasmic dynein. Mutations within the highly conserved CAP-Gly domain of dynactin cause neurodegenerative disease. Here, we show that the CAP-Gly domain is necessary to enrich dynactin at the distal end of primary neuron...
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| Main Authors: | , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3347924/ https://ncbi.nlm.nih.gov/pubmed/22542186 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2012.02.025 |
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