Mechanism of hypochlorous acid mediated heme destruction and free iron release

Here, we show that hypochlorous acid (HOCl), a potent neutrophil generated oxidant, can mediate destruction of free heme (Ht) and the heme precursor, protoporphyrin IX (PPIX). Ht display a broad Soret peak centered at 365 and 394 nm, indicative of the presence of monomer and μ-oxo-dimer. Oxidation o...

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Autors principals: Maitra, Dhiman, Byun, Jaeman, Andreana, Peter R., Abdulhamid, Ibrahim, Saed, Ghassan M., Diamond, Michael P., Pennathur, Subramaniam, Abu-Soud, Husam M.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378337/
https://ncbi.nlm.nih.gov/pubmed/21466849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2011.03.040
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