REACTION OF HEMOGLOBIN WITH HOCl: MECHANISM OF HEME DESTRUCTION AND FREE IRON RELEASE

Hypochlorous acid (HOCl) is generated by myeloperoxidase (MPO), using chloride and hydrogen peroxide as substrate. HOCl and its conjugate base (OCl(−)) bind to the heme moiety of hemoglobin (Hb) and generate a transient ferric species whose formation and decay kinetics indicate it can participate in...

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Detalhes bibliográficos
Main Authors: Maitra, Dhiman, Byun, Jaeman, Andreana, Peter R., Abdulhamid, Ibrahim, Diamond, Michael P., Saed, Ghassan M., Pennathur, Subramaniam, Abu-Soud, Husam M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3863628/
https://ncbi.nlm.nih.gov/pubmed/21549834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2011.04.011
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