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Mechanism of hypochlorous acid mediated heme destruction and free iron release
Here, we show that hypochlorous acid (HOCl), a potent neutrophil generated oxidant, can mediate destruction of free heme (Ht) and the heme precursor, protoporphyrin IX (PPIX). Ht display a broad Soret peak centered at 365 and 394 nm, indicative of the presence of monomer and μ-oxo-dimer. Oxidation o...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3378337/ https://ncbi.nlm.nih.gov/pubmed/21466849 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2011.03.040 |
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