Hypochlorous Acid-Induced Heme Degradation from Lactoperoxidase as a Novel Mechanism of Free Iron Release and Tissue Injury in Inflammatory Diseases

Lactoperoxidase (LPO) is the major consumer of hydrogen peroxide (H(2)O(2)) in the airways through its ability to oxidize thiocyanate (SCN(−)) to produce hypothiocyanous acid, an antimicrobial agent. In nasal inflammatory diseases, such as cystic fibrosis, both LPO and myeloperoxidase (MPO), another...

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Detalhes bibliográficos
Main Authors: Souza, Carlos Eduardo A., Maitra, Dhiman, Saed, Ghassan M., Diamond, Michael P., Moura, Arlindo A., Pennathur, Subramaniam, Abu-Soud, Husam M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3222650/
https://ncbi.nlm.nih.gov/pubmed/22132121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027641
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