Mice lacking macrophage 12/15-lipoxygenase are resistant to experimental hypertension

In mouse arteries, Alox15 [leukocyte-type 12/15-lipoxygenase (LO)] is assumed to regulate vascular function by metabolizing arachidonic acid (AA) to dilator eicosanoids that mediate the endothelium-dependent relaxations to AA and acetylcholine (ACh). We used Alox15(−/−) mice, made by targeted disrup...

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Bibliografiske detaljer
Main Authors: Kriska, Tamas, Cepura, Cody, Magier, Devora, Siangjong, Lawan, Gauthier, Kathryn M., Campbell, William B.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2012
Fag:
Integrative Cardiovascular Physiology and Pathophysiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378305/
https://ncbi.nlm.nih.gov/pubmed/22467300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.01120.2011
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