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Mice lacking macrophage 12/15-lipoxygenase are resistant to experimental hypertension
In mouse arteries, Alox15 [leukocyte-type 12/15-lipoxygenase (LO)] is assumed to regulate vascular function by metabolizing arachidonic acid (AA) to dilator eicosanoids that mediate the endothelium-dependent relaxations to AA and acetylcholine (ACh). We used Alox15(−/−) mice, made by targeted disrup...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3378305/ https://ncbi.nlm.nih.gov/pubmed/22467300 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.01120.2011 |
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