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Optical Tweezers Studies on Notch: Single-molecule Interaction Strength is Independent of Ligand Endocytosis

Notch signaling controls diverse cellular processes critical to development and disease. Cell surface ligands bind Notch on neighboring cells yet require endocytosis to activate signaling. The role ligand endocytosis plays in Notch activation has not been established. Here we integrate optical tweez...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Shergill, Bhupinder, Meloty-Kapella, Laurence, Musse, Abdiwahab A., Weinmaster, Gerry, Botvinick, Elliot
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3376165/
https://ncbi.nlm.nih.gov/pubmed/22658935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2012.04.007
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