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Notch Ligand Endocytosis Generates Mechanical Pulling Force Dependent on Dynamin, Epsins and Actin

Notch signaling induced by cell surface ligands is critical to development and maintenance of many eukaryotic organisms. Notch and its ligands are integral membrane proteins that facilitate direct cell-cell interactions to activate Notch proteolysis and release the intracellular domain that directs...

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Detalhes bibliográficos
Main Authors: Meloty-Kapella, Laurence, Shergill, Bhupinder, Kuon, Jane, Botvinick, Elliot, Weinmaster, Gerry
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3400432/
https://ncbi.nlm.nih.gov/pubmed/22658936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2012.04.005
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