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Epsin-dependent ligand endocytosis activates Notch by force
DSL ligands activate Notch by inducing cleavage and shedding of the receptor ectodomain—an event that requires ligand to be endocytosed in signal-sending cells by the adaptor protein Epsin. Two classes of explanation for this unusual requirement are: (i) recycling models, in which ligand must be end...
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| Publicado no: | Cell |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6219616/ https://ncbi.nlm.nih.gov/pubmed/29195077 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.10.048 |
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